Empagliflozin Impurity 181

Empagliflozin Impurity 181 - Names and Identifiers

Name	methyl 5-bromo-2-chlorobenzoate
Synonyms	Empagliflozin Impurity 181 methyl 5-bromo-2-chlorobenzoate 2-Chloro-5-broMobenzoic acid Methyl ester Benzoic acid, 5-bromo-2-chloro-, methyl ester benzoic acid, 5-bromo-2-chloro-, methyl ester
CAS	251085-87-7
InChI	InChI=1/C8H6BrClO2/c1-12-8(11)6-4-5(9)2-3-7(6)10/h2-4H,1H3

Empagliflozin Impurity 181 - Physico-chemical Properties

Molecular Formula	C8H6BrClO2
Molar Mass	249.49
Density	1.604±0.06 g/cm3(Predicted)
Melting Point	43-44 °C
Boling Point	276.0±20.0 °C(Predicted)
Flash Point	120.7°C
Vapor Presure	0.00491mmHg at 25°C
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.564

Empagliflozin Impurity 181 - Introduction

methyl 5-bromo-2-chlorobenzoate is an organic compound. The following is a description of its nature, use, formulation and safety information:

Nature:
-chemical formula: C8H6BrClO2
-Molecular weight: 241.49g/mol
-Appearance: Colorless to slightly yellow solid
-Melting point: 54-57 ° C
-Boiling point: 306-309 ° C
-Low solubility in water

Use:
methyl 5-bromo-2-chlorobenzoate is commonly used as an intermediate in organic synthesis and can be used to synthesize biologically active compounds. It can be used as a starting material for the synthesis of drugs, pesticides and dyes, and can also be used in substitution reactions, tandem reactions and aromatization reactions in organic synthesis reactions.

Method:
methyl 5-bromo-2-chlorobenzoate can be prepared by reacting methyl benzoate suspension with bromine in the presence of ferrous chloride. First, methyl benzoate was mixed with a ferrous chloride solution, bromine was added, and the mixture was stirred at normal temperature. After the reaction, the target product methyl 5-bromo-2-chlorobenzoate was obtained by acidic process treatment and crystallization purification.

Safety Information:
- methyl 5-bromo-2-chlorobenzoate is an organic compound and must be handled carefully to avoid direct contact with the skin and inhalation.
-Wear personal protective equipment such as lab gloves, goggles and lab coats when operating.
-When storing, keep it in a cool, dry and sealed container, away from fire and oxidizing agents.
-Please follow the local chemical waste treatment method when disposing to avoid pollution to the environment.
-When using or handling the compound, please refer to the relevant safety documents and operating instructions, and follow the correct laboratory safety operating procedures.

Last Update：2024-04-09 21:01:54